| ncRNA name | hsa-miR-126 |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal pericytes (HRP) |
| Methods | qRT-PCR, Western blot, FACS |
| Expression pattern | down-regulated |
| Functional description | HRP express miR-126, and this expression is down-regulated in intermittent high glucose. MSC-derived EV obtained in hyperglycaemic/hypoxic conditions down-regulate miR-126 expression in pericytes, leading to increased expression of angiogenic molecules, such as VEGF and HIF-1α. |
| PubMed ID | 26282100 |
| Year | 2015 |
| Title | Molecular mechanisms of extracellular vesicle-induced vessel destabilization in diabetic retinopathy. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.